Vingegaard seizes control of Paris-Nice with stage 4 win
The imperious Dane took the race-leader's yellow jersey after attacking Red Bull-Bora pair Daniel Martinez and Tim van Dijke on the steep final climb, one kilometre from the finish of the 195km stage from Bourges to Uchon.
Colombian Martinez was second at the summit, 41sec adrift, and now trails Vingegaard by 52sec overall in the eight-day race.
German Georg Steinhauser is third overall 3:20 back after coming home fifth on the day almost three minutes after the winner.
Cross-winds early on caused havoc and split the peloton into several groups.
In driving rain and cold conditions that forced riders to wrap up, the slippery surface also caused several riders to crash, including overnight leader Juan Ayuso of Spain.
Ayuso was taken away by ambulance and another overall contender in Team UAE's Brandon McNulty also withdrew after a heavy fall.
Three of Martinez's Red Bull teammates drove the pace at the front until he and Vingegaard were the only overall contenders left to contest the stage victory.
Ineos's French recruit Kevin Vauquelin battled to sixth on the day despite being dropped early on in the cross-winds, leaving him now fourth overall at 3min 39sec.
Three hilly stages and a big mountain run on Saturday remain, with Thursday's stage five featuring an uphill finale and three climbs in the final 40km.