Newcastle must grow under Camp Nou pressure: Howe
The Premier League club outplayed the Spanish champions in the last 16 first leg, but a late Lamine Yamal penalty to snatched a 1-1 draw last week on Tyneside.
Newcastle, aiming to reach the Champions League quarter-finals for the first time in the club's history, know the challenge will be different on Wednesday at the home of the five-time winners.
"I don't think they will (be overawed), we've got an experienced group, we've got many players who have played in so many big games now we've become accustomed to it," Howe said.
"You almost want that size of the game to lift the players and to make us grow -- certainly we can't shrink -- but with many, many internationals within the squad I don't see that as an issue.
"It's just making sure from my side that we get the plan right, they've got a lot of dangerous players that we need to deal with."
Newcastle are ninth in the Premier League in a frustrating campaign, but Howe said the club are in their best moment of the season.
"(The players) are the happiest they have been throughout the season, it's been one of a lot of change... early season we struggled to find our rhythm, our relationships in the team were new," continued Howe.
"Their confidence was affected slightly. We worked really hard to try and bring some stability to the team."
"In the last few weeks we've returned to a really good flow. It's been a much better feel, better individual performances in return, better collective performances."
Newcastle beat Chelsea 1-0 on Saturday with a strong defensive display, which Howe said the team would have to draw from against the likes of Raphinha and teenage star Yamal.
"You have to be optimistic and you have to be positive, and that's why the Chelsea result and performance was so important," explained Howe.
"We proved to ourselves that we can defend our goal really well... I think we're as good a place as we've been at any stage this season, both on and off the pitch.
"We had to be in this position to give ourselves the best chance, and now we're just putting it over the line."
'Really confident'
Barcelona beat Newcastle 2-1 in the league phase at St James' Park before last week's draw, but Newcastle defender Kieran Trippier said his team were on a high heading into the clash against the La Liga leaders.
"Yeah, we feel really confident, (although) I think we've had a mixed season," Trippier told reporters.
"There's a really good feeling around the place, so we come here calm and relaxed, looking forward to the game tomorrow, it's a big opportunity, and we know the rewards are going to be there if we put in a good performance."
Howe said the game at Camp Nou was "probably" the biggest of his career and Trippier defended his coach against some criticism he has received this term.
"I have great respect for what he's done for this football club, he's remarkable," added the defender.