Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose
by Zhiyuan Ma, Ping Wang, Zehui Gao, Ruobing Wang, Koroush Khalighi
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic variants such as polymorphisms in CYP2C9 and VKORC1. The most widely validated pharmacogenetic algorithm is... Читать дальше...