Relaxed constraint and functional divergence of the progesterone receptor (PGR) in the human stem-lineage
by Mirna Marinić, Vincent J. Lynch
The steroid hormone progesterone, acting through the progesterone receptor (PR), a ligand-activated DNA-binding transcription factor, plays an essential role in regulating nearly every aspect of female reproductive biology. While many reproductive traits regulated by PR are conserved in mammals, Catarrhine primates evolved several derived traits including spontaneous decidualization, menstruation, and a divergent (and unknown) parturition signal, suggesting... Читать дальше...