Alli, Lloris and Sissoko miss Inter-Tottenham in Champions League
Having sat out Saturday's 2-1 home loss to Liverpool in the Premier League, all three players will not feature in Milan on Tuesday.
Lloris is expected to be out for "several weeks" with a thigh injury but Alli's hamstring problem, sustained on international duty with England, is less serious.
Sissoko also has a hamstring injury and will not be available for the San Siro fixture, the first for both teams in Group B.
TEAM NEWS: @dele_official (hamstring), Hugo Lloris (thigh) and @MoussaSissoko (hamstring) all remain unavailable due to injury. pic.twitter.com/1iS0MVu1Ks
— Tottenham Hotspur (@SpursOfficial) September 17, 2018